Description
Product Characteristics:
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
Subcellular location: Extracellular
Synonyms: IRC1, IRC2, CLM-8, IRp60, IGSF12, CMRF35H, CMRF-35H, CMRF35-H, CMRF35H9, CMRF35-H9, IRC1/IRC2, CMRF-35-H9, CMRF35-like molecule 8, CD300 antigen-like family member A, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a, HSPC083
Target Information: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]